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Further unwanted side effects can be experienced due to heightened oestrogen levels, that build up during a sustanon 250 cycle, due to aromatization (the conversion of testosterone into oestrogen)and estrogen conversion (the conversion of estrogen into an estrogen receptor (ER) agonist, which activates the ER). Some women will experience breast development (e.g., cysts). Treatment with a feminizing hormone can be achieved by injecting a combination containing estrogen and progesterone and progesterone only for three weeks. For this to work, progesterone must be increased by about 1 mg/day (the equivalent of one pill for an adult woman; one pill for an 11-year-old girl). Many will be able to reduce the dose of estrogen because of their tolerance to the estrogen. However, the goal is to reduce the oestrogen level from about 10-25 to 20 or less over the course of the cycle. If there is not a progesterone receptor agonist available after three weeks, progesterone may be used to help manage residual estradiol, which is the natural estrogen, after this medication is discontinued. Treatment with estrogen-progesterone (E-P) also needs to be adjusted to take advantage of this receptor and to allow for the reduction of estrogen levels if estrogen levels are high. After three weeks, when progesterone is adequate, injections of 100 mcg of estradiol may be used to stimulate the oestrogen receptors. These should be repeated weekly or on an as needed basis, at least for as long as the estrogen is necessary to reduce the levels. If it is not possible to have both estradiol and progesterone delivered at the same time, progesterone is then used. In a women who has ovaries with reduced ovulation, if an estradiol progesterone injection is not administered as a single dose, then after the first day of each month, progesterone injections on the third day of the month will allow the ovaries to begin to produce sufficient hormones to prevent an ovulation and then a subsequent round of oestrogen injection. Again, the goal is to reduce the levels. Treatment with the E-P formulation is less expensive and a shorter supply of the E-P hormone can be obtained before the cycle. For long-term cycles with increased estrogen levels, however, the use of such a formulation may not be a suitable option. Treatment of secondary hyperandrogenism will require long-term treatment with the E-P formulation (generally every 6 months). Although most women can safely and effectively administer estrogen-progesterone to reduce Related Article: